PTPIB inhibitors from

A new lignaii glycoside, named !,5-iJihydroxypinoresinol^'-O-p-[)-gIucopyrano.siiJe (1). lias heen isolated from lhe EtOH extract of the roots of Suussurea lappa. together wilh twenty known compounds: (+)-l-hydroxypinoresinol-l-O-p-[j-glua)pyranosidc (2). fraxiresinol-4'-0-p-n-gliicopyranosidc (3). ( )-olivH-4"-0-p-[)-ylucopyninoside (4). 4-allyl-2.6-dimethoxybcn/.cne-1 -(7-(l-D-glucopyranoside, syringin. coslunoiide-15-O-ti-ti-gluL-opyrano^ide. chlorogenic acid, aliK"-cnu)diTi-8-O-p-t)-glucopyranoside (5), rhein-H-CJ-|i-D-glucopyrariosidc (6), chrysophanol l7). ernodin. dchydrocosius lactone. costunnlide. P-cosiic acid, reyiiosin. arbusculin A, a-cyclncostunolide. p-cydofostiinolide, siintamarim.' and magnolialide. Three anthraqiiinones (5-7) showed moderate bioactivity against human Protein Tyrosine Phosphata.sc IB (hPTPIB) in viiiv.